\npH\uff08\u6c34\u6eb6\u6db2\uff09<\/td>\n | 7.5 \u2013 8.2<\/td>\n | \u2014<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u53ef\u4ee5\u770b\u5230\uff0c\u5b83\u4e0d\u4ec5\u7194\u70b9\u4f4e\uff0c\u7c98\u5ea6\u9002\u4e2d\uff0c\u800c\u4e14pH\u63a5\u8fd1\u4e2d\u6027\uff0c\u9002\u5408\u4e0e\u751f\u7269\u7cfb\u7edf\u517c\u5bb9\u3002<\/p>\n 3. \u73af\u4fdd\u53cb\u597d\uff0c\u7eff\u8272\u5316\u5b66\u7684\u9996\u9009<\/h3>\n\u76f8\u8f83\u4e8e\u4f20\u7edf\u6709\u673a\u6eb6\u5242\u5982DMF\u3001THF\u7b49\uff0cDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u5177\u6709\u66f4\u4f4e\u7684\u6bd2\u6027\u548c\u66f4\u9ad8\u7684\u53ef\u964d\u89e3\u6027\u3002\u5b83\u4e0d\u6325\u53d1\u3001\u4e0d\u6613\u71c3\u3001\u65e0\u523a\u6fc0\u6c14\u5473<\/strong>\uff0c\u662f\u7eff\u8272\u5316\u5b66\u7684\u7406\u60f3\u66ff\u4ee3\u54c1\u3002<\/p>\n\u6b64\u5916\uff0c\u7531\u4e8e\u5176\u79bb\u5b50\u7ed3\u6784\uff0c\u5b83\u5728\u4f7f\u7528\u540e\u53ef\u4ee5\u901a\u8fc7\u7b80\u5355\u7684\u5904\u7406\u56de\u6536\u518d\u5229\u7528\uff0c\u5927\u5927\u964d\u4f4e\u4e86\u73af\u5883\u6c61\u67d3\u98ce\u9669\u3002<\/p>\n \n\u4e09\u3001\u5b9e\u9645\u5e94\u7528\u6848\u4f8b\uff1a\u4ece\u5b9e\u9a8c\u5ba4\u5230\u5de5\u4e1a\u73b0\u573a<\/h2>\n1. \u50ac\u5316\u53cd\u5e94\u4e2d\u7684\u201c\u9690\u5f62\u63a8\u624b\u201d<\/h3>\nDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u4f5c\u4e3a\u53cd\u5e94\u4ecb\u8d28\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5404\u7c7b\u50ac\u5316\u53cd\u5e94\u4e2d\uff0c\u5c24\u5176\u662f\u5728\u916f\u4ea4\u6362\u53cd\u5e94\u3001Knoevenagel\u7f29\u5408\u3001Michael\u52a0\u6210<\/strong>\u7b49\u7ecf\u5178\u6709\u673a\u5408\u6210\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u8272\u3002<\/p>\n\u4f8b\u5982\uff0c\u5728\u4e00\u9879\u5173\u4e8eMichael\u52a0\u6210\u7684\u7814\u7a76\u4e2d\uff0c\u7814\u7a76\u4eba\u5458\u53d1\u73b0\u4f7f\u7528DBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u4ee3\u66ff\u4f20\u7edf\u6eb6\u5242\u65f6\uff0c\u53cd\u5e94\u8f6c\u5316\u7387\u63d0\u9ad8\u4e8625%\u4ee5\u4e0a<\/strong>\uff0c\u4e14\u526f\u4ea7\u7269\u663e\u8457\u51cf\u5c11\u3002<\/p>\n\n\n\n\u5b9e\u9a8c\u6761\u4ef6<\/th>\n | \u6eb6\u5242\u7c7b\u578b<\/th>\n | \u8f6c\u5316\u7387<\/th>\n | \u53cd\u5e94\u65f6\u95f4<\/th>\n<\/tr>\n<\/thead>\n | \n\n\u4f20\u7edf\u6eb6\u5242<\/td>\n | THF<\/td>\n | 68%<\/td>\n | 8\u5c0f\u65f6<\/td>\n<\/tr>\n | \nDBU\u00b2-2-EH\u76d0<\/td>\n | DBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0<\/td>\n | 93%<\/td>\n | 5\u5c0f\u65f6<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u8fd9\u8bf4\u660e\u8be5\u79bb\u5b50\u6db2\u4f53\u4e0d\u4ec5\u80fd\u63d0\u9ad8\u53cd\u5e94\u6548\u7387\uff0c\u8fd8\u80fd\u7f29\u77ed\u53cd\u5e94\u5468\u671f\uff0c\u53ef\u8c13\u201c\u7701\u65f6\u53c8\u9ad8\u6548\u201d\u3002<\/p>\n 2. \u836f\u7269\u6eb6\u89e3\u4e0e\u9012\u9001\u7684\u65b0\u5ba0\u513f<\/h3>\n\u5728\u5236\u836f\u9886\u57df\uff0c\u5f88\u591a\u6d3b\u6027\u6210\u5206\u56e0\u4e3a\u96be\u6eb6\u800c\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002DBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u51ed\u501f\u5176\u4f18\u5f02\u7684\u6eb6\u89e3\u80fd\u529b\u548c\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u6210\u4e3a\u836f\u7269\u589e\u6eb6\u5242<\/strong>\u7684\u7406\u60f3\u5019\u9009\u3002<\/p>\n\u6709\u7814\u7a76\u56e2\u961f\u5c06\u5176\u7528\u4e8e\u6eb6\u89e3\u6297\u80bf\u7624\u836f\u7269\u7d2b\u6749\u9187\uff08Paclitaxel\uff09\uff0c\u7ed3\u679c\u663e\u793a\u5728\u8be5\u6eb6\u5242\u4e2d\u7d2b\u6749\u9187\u7684\u6eb6\u89e3\u5ea6\u63d0\u9ad8\u4e86\u8fd110\u500d<\/strong>\uff0c\u5e76\u4e14\u65e0\u9700\u6dfb\u52a0\u8868\u9762\u6d3b\u6027\u5242\u5373\u53ef\u5b9e\u73b0\u5747\u5300\u5206\u6563\u3002<\/p>\n <\/p>\n
\u6709\u7814\u7a76\u56e2\u961f\u5c06\u5176\u7528\u4e8e\u6eb6\u89e3\u6297\u80bf\u7624\u836f\u7269\u7d2b\u6749\u9187\uff08Paclitaxel\uff09\uff0c\u7ed3\u679c\u663e\u793a\u5728\u8be5\u6eb6\u5242\u4e2d\u7d2b\u6749\u9187\u7684\u6eb6\u89e3\u5ea6\u63d0\u9ad8\u4e86\u8fd110\u500d<\/strong>\uff0c\u5e76\u4e14\u65e0\u9700\u6dfb\u52a0\u8868\u9762\u6d3b\u6027\u5242\u5373\u53ef\u5b9e\u73b0\u5747\u5300\u5206\u6563\u3002<\/p>\n\n\n\n\u836f\u7269\u540d\u79f0<\/th>\n | \u6eb6\u5242\u79cd\u7c7b<\/th>\n | \u6eb6\u89e3\u5ea6\uff08mg\/mL\uff09<\/th>\n | \u5907\u6ce8<\/th>\n<\/tr>\n<\/thead>\n | \n\n\u7d2b\u6749\u9187<\/td>\n | \u6c34<\/td>\n | 0.3<\/td>\n | \u51e0\u4e4e\u4e0d\u6eb6<\/td>\n<\/tr>\n | \n\u7d2b\u6749\u9187<\/td>\n | DBU\u00b2-2-EH\u76d0<\/td>\n | 3.2<\/td>\n | \u663e\u8457\u63d0\u5347<\/td>\n<\/tr>\n | \n\u963f\u53f8\u5339\u6797<\/td>\n | DBU\u00b2-2-EH\u76d0<\/td>\n | 15.5<\/td>\n | \u5ba4\u6e29\u4e0b\u5feb\u901f\u6eb6\u89e3<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u8fd9\u6837\u7684\u6570\u636e\u65e0\u7591\u8ba9\u836f\u4f01\u4eec\u773c\u524d\u4e00\u4eae\u3002<\/p>\n 3. \u6750\u6599\u79d1\u5b66\u4e2d\u7684\u201c\u591a\u9762\u624b\u201d<\/h3>\n\u5728\u6750\u6599\u5408\u6210\u65b9\u9762\uff0cDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u4e5f\u5c55\u73b0\u51fa\u4e86\u975e\u51e1\u7684\u9002\u5e94\u6027\u3002\u5b83\u53ef\u7528\u4e8e\u7eb3\u7c73\u7c92\u5b50\u5236\u5907\u3001\u805a\u5408\u7269\u6539\u6027\u3001\u7535\u6781\u6750\u6599\u5408\u6210<\/strong>\u7b49\u591a\u4e2a\u65b9\u5411\u3002<\/p>\n\u6bd4\u5982\u5728\u9502\u79bb\u5b50\u7535\u6c60\u7535\u89e3\u6db2\u6dfb\u52a0\u5242\u4e2d\uff0c\u8be5\u79bb\u5b50\u6db2\u4f53\u80fd\u591f\u6709\u6548\u63d0\u9ad8\u7535\u89e3\u6db2\u7684\u5bfc\u7535\u6027\u548c\u7a33\u5b9a\u6027\uff0c\u540c\u65f6\u6291\u5236\u679d\u6676\u751f\u957f\uff0c\u5ef6\u957f\u7535\u6c60\u5bff\u547d\u3002<\/p>\n \n\n\n\u6dfb\u52a0\u6bd4\u4f8b<\/th>\n | \u7535\u5bfc\u7387\u63d0\u5347\u5e45\u5ea6<\/th>\n | \u5faa\u73af\u5bff\u547d\u589e\u52a0<\/th>\n<\/tr>\n<\/thead>\n | \n\n5%<\/td>\n | 20%<\/td>\n | 30%<\/td>\n<\/tr>\n | \n10%<\/td>\n | 35%<\/td>\n | 50%<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \u8fd9\u8868\u660e\uff0c\u5373\u4f7f\u5c11\u91cf\u6dfb\u52a0\u4e5f\u80fd\u5e26\u6765\u663e\u8457\u6027\u80fd\u63d0\u5347\u3002<\/p>\n \n\u56db\u3001\u4ea7\u54c1\u53c2\u6570\u4e00\u89c8\u8868\uff1a\u4e70\u4e4b\u524d\u5fc5\u770b\uff01<\/h2>\n\u4e3a\u4e86\u8ba9\u5927\u5bb6\u66f4\u76f4\u89c2\u5730\u4e86\u89e3\u8fd9\u6b3e\u4ea7\u54c1\u7684\u5404\u9879\u6027\u80fd\u6307\u6807\uff0c\u6211\u4eec\u6574\u7406\u4e86\u4e00\u4efd\u8be6\u7ec6\u7684\u53c2\u6570\u8868\uff1a<\/p>\n \n\n\n\u9879\u76ee\u540d\u79f0<\/th>\n | \u53c2\u6570\u503c<\/th>\n | \u5355\u4f4d<\/th>\n<\/tr>\n<\/thead>\n | \n\n\u5316\u5b66\u540d\u79f0<\/td>\n | DBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u5206\u5b50\u5f0f<\/td>\n | C\u2082\u2080H\u2084\u2080N\u2082O\u2084<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u5206\u5b50\u91cf<\/td>\n | 372.5<\/td>\n | g\/mol<\/td>\n<\/tr>\n | \n\u5916\u89c2<\/td>\n | \u900f\u660e\u81f3\u6de1\u9ec4\u8272\u6db2\u4f53<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u7194\u70b9<\/td>\n | -45 ~ -30<\/td>\n | \u00b0C<\/td>\n<\/tr>\n | \n\u5206\u89e3\u6e29\u5ea6<\/td>\n | >200<\/td>\n | \u00b0C<\/td>\n<\/tr>\n | \n\u7c98\u5ea6\uff0825\u00b0C\uff09<\/td>\n | 200 \u2013 400<\/td>\n | mPa\u00b7s<\/td>\n<\/tr>\n | \n\u5bc6\u5ea6\uff0825\u00b0C\uff09<\/td>\n | 0.98 \u2013 1.02<\/td>\n | g\/cm\u00b3<\/td>\n<\/tr>\n | \npH\uff08\u6c34\u6eb6\u6db2\uff09<\/td>\n | 7.5 \u2013 8.2<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u5438\u6e7f\u6027<\/td>\n | \u4e2d\u7b49<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u53ef\u71c3\u6027<\/td>\n | \u4e0d\u6613\u71c3<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u6bd2\u6027\uff08LD\u2085\u2080\uff09<\/td>\n | >2000 mg\/kg\uff08\u5c0f\u9f20\u53e3\u670d\uff09<\/td>\n | \u2014<\/td>\n<\/tr>\n | \n\u63a8\u8350\u50a8\u5b58\u6e29\u5ea6<\/td>\n | \u5ba4\u6e29\uff0c\u907f\u5149\u5bc6\u5c01\u4fdd\u5b58<\/td>\n | \u00b0C<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n \ud83d\udccc \u5c0f\u8d34\u58eb<\/strong>\uff1a\u867d\u7136DBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u6bd2\u6027\u8f83\u4f4e\uff0c\u4f46\u4ecd\u5efa\u8bae\u4f69\u6234\u9632\u62a4\u624b\u5957\u548c\u62a4\u76ee\u955c\u64cd\u4f5c\uff0c\u907f\u514d\u957f\u65f6\u95f4\u76ae\u80a4\u63a5\u89e6\u3002<\/p>\n \n\u4e94\u3001\u672a\u6765\u5c55\u671b\uff1a\u8c01\u5c06\u5f15\u9886\u4e0b\u4e00\u4ee3\u7eff\u8272\u6eb6\u5242\u9769\u547d\uff1f<\/h2>\n\u968f\u7740\u5168\u7403\u5bf9\u53ef\u6301\u7eed\u53d1\u5c55\u548c\u7eff\u8272\u5236\u9020\u7684\u5173\u6ce8\u65e5\u76ca\u589e\u5f3a\uff0c\u4f20\u7edf\u7684\u9ad8\u6bd2\u6027\u3001\u9ad8\u6325\u53d1\u6027\u6eb6\u5242\u6b63\u9010\u6e10\u88ab\u6dd8\u6c70\u3002\u800c\u50cfDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u8fd9\u6837\u5b89\u5168\u3001\u9ad8\u6548\u3001\u73af\u4fdd<\/strong>\u7684\u65b0\u578b\u79bb\u5b50\u6db2\u4f53\uff0c\u6b63\u5728\u6210\u4e3a\u884c\u4e1a\u8f6c\u578b\u7684\u5173\u952e\u529b\u91cf\u3002<\/p>\n\u5728\u672a\u6765\uff0c\u6211\u4eec\u53ef\u4ee5\u671f\u5f85\u5b83\u5728\u4ee5\u4e0b\u51e0\u4e2a\u65b9\u5411\u53d6\u5f97\u7a81\u7834\uff1a<\/p>\n \n- \u751f\u7269\u533b\u836f<\/strong>\uff1a\u4f5c\u4e3a\u9776\u5411\u836f\u7269\u8f7d\u4f53\u6216\u86cb\u767d\u7a33\u5b9a\u5242<\/li>\n
- \u80fd\u6e90\u6750\u6599<\/strong>\uff1a\u7528\u4e8e\u56fa\u6001\u7535\u89e3\u8d28\u3001\u71c3\u6599\u7535\u6c60\u7b49<\/li>\n
- \u73af\u5883\u5de5\u7a0b<\/strong>\uff1a\u7528\u4e8e\u6c61\u67d3\u7269\u63d0\u53d6\u3001\u91cd\u91d1\u5c5e\u5438\u9644<\/li>\n
- \u5316\u5986\u54c1\u4e0e\u65e5\u5316<\/strong>\uff1a\u4f5c\u4e3a\u6e29\u548c\u6eb6\u5242\u3001\u4e73\u5316\u5242\u4f7f\u7528<\/li>\n<\/ul>\n
\ud83d\udd2c \u4e00\u53e5\u8bdd\u603b\u7ed3<\/strong>\uff1aDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\uff0c\u4e0d\u53ea\u662f\u4e00\u4e2a\u79bb\u5b50\u6db2\u4f53\uff0c\u66f4\u662f\u7eff\u8272\u5316\u5b66\u65f6\u4ee3\u7684\u4e00\u628a\u94a5\u5319\u3002<\/p>\n \n\u516d\u3001\u6587\u732e\u53c2\u8003\uff1a\u7ad9\u5728\u5de8\u4eba\u7684\u80a9\u8180\u4e0a\u770b\u4e16\u754c \ud83d\udcda<\/h2>\n\u4ee5\u4e0b\u662f\u56fd\u5185\u5916\u4e00\u4e9b\u5173\u4e8eDBU\u00b2-2-\u4e59\u57fa\u5df1\u9178\u76d0\u53ca\u5176\u76f8\u5173\u79bb\u5b50\u6db2\u4f53\u7684\u7814\u7a76\u6587\u732e\uff0c\u4f9b\u611f\u5174\u8da3\u7684\u8bfb\u8005\u8fdb\u4e00\u6b65\u67e5\u9605\uff1a<\/p>\n | | | | |