{"id":10170,"date":"2025-06-12T20:57:55","date_gmt":"2025-06-12T12:57:55","guid":{"rendered":"https:\/\/www.shorro.cn\/index.php\/archives\/10170"},"modified":"2025-06-12T20:57:55","modified_gmt":"2025-06-12T12:57:55","slug":"%e5%af%bb%e6%89%be%e5%85%b7%e6%9c%89%e4%bc%98%e5%bc%82%e5%82%ac%e5%8c%96%e6%b4%bb%e6%80%a7%e7%9a%84dbu%e8%8b%af%e9%85%9a%e7%9b%90%e4%ba%a7%e5%93%81","status":"publish","type":"post","link":"https:\/\/www.shorro.cn\/index.php\/archives\/10170","title":{"rendered":"\u5bfb\u627e\u5177\u6709\u4f18\u5f02\u50ac\u5316\u6d3b\u6027\u7684DBU\u82ef\u915a\u76d0\u4ea7\u54c1"},"content":{"rendered":"<h1>DBU\u82ef\u915a\u76d0\uff1a\u4e00\u79cd\u5177\u6709\u4f18\u5f02\u50ac\u5316\u6d3b\u6027\u7684\u6709\u673a\u78b1\u50ac\u5316\u5242<\/h1>\n<hr \/>\n<h2>\u5f15\u8a00\uff1a\u4ece\u4e00\u676f\u5496\u5561\u5230\u4e00\u573a\u5316\u5b66\u53cd\u5e94<\/h2>\n<p>\u5982\u679c\u4f60\u662f\u4e00\u4e2a\u70ed\u7231\u751f\u6d3b\u3001\u53c8\u7565\u61c2\u5316\u5b66\u7684\u4eba\uff0c\u90a3\u4f60\u4e00\u5b9a\u77e5\u9053\uff0c\u751f\u6d3b\u4e2d\u5f88\u591a\u770b\u4f3c\u201c\u7406\u6240\u5f53\u7136\u201d\u7684\u4e8b\u60c5\u80cc\u540e\uff0c\u5176\u5b9e\u90fd\u85cf\u7740\u4e0d\u5c11\u79d1\u5b66\u7684\u5c0f\u79d8\u5bc6\u3002\u6bd4\u5982\u4f60\u65e9\u4e0a\u6ce1\u7684\u4e00\u676f\u5496\u5561\uff0c\u9999\u6c14\u56db\u6ea2\u7684\u80cc\u540e\u662f\u590d\u6742\u7684\u6325\u53d1\u6027\u7269\u8d28\u5728\u8d77\u4f5c\u7528\uff1b\u800c\u4f60\u5728\u5b9e\u9a8c\u5ba4\u91cc\u505a\u7684\u4e00\u6b21\u7f29\u5408\u53cd\u5e94\uff0c\u4e5f\u8bb8\u6b63\u4f9d\u8d56\u4e8e\u4e00\u4e2a\u4e0d\u8d77\u773c\u5374\u81f3\u5173\u91cd\u8981\u7684\u50ac\u5316\u5242\u2014\u2014DBU\u82ef\u915a\u76d0\u3002<\/p>\n<p>\u4eca\u5929\uff0c\u6211\u4eec\u5c31\u6765\u804a\u804a\u8fd9\u4e2a\u542c\u8d77\u6765\u6709\u70b9\u62d7\u53e3\u4f46\u5b9e\u5219\u5927\u6709\u6765\u5934\u7684\u5316\u5408\u7269\uff1a<strong>DBU\u82ef\u915a\u76d0<\/strong>\uff081,8-Diazabicyclo[5.4.0]undec-7-ene Phenolate\uff09\u3002\u5b83\u4e0d\u4ec5\u540d\u5b57\u957f\u5f97\u50cf\u7ed5\u53e3\u4ee4\uff0c\u66f4\u91cd\u8981\u7684\u662f\uff0c\u5b83\u5728\u8bb8\u591a\u6709\u673a\u5408\u6210\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u4e86\u4ee4\u4eba\u60ca\u8273\u7684\u50ac\u5316\u6d3b\u6027\u3002<\/p>\n<p>\u522b\u770b\u5b83\u540d\u5b57\u590d\u6742\uff0c\u5b9e\u9645\u4e0a\u5b83\u5c31\u50cf\u662f\u4e00\u4f4d\u7a7f\u7740\u897f\u88c5\u6253\u7740\u9886\u5e26\u7684\u7ec5\u58eb\uff0c\u4f18\u96c5\u5730\u7ad9\u5728\u53cd\u5e94\u74f6\u65c1\u8fb9\uff0c\u5fae\u7b11\u7740\u5bf9\u53cd\u5e94\u8bf4\uff1a\u201c\u8ba9\u6211\u6765\u5e2e\u5e2e\u4f60\u3002\u201d<\/p>\n<hr \/>\n<h2>\u7b2c\u4e00\u7ae0\uff1a\u4ec0\u4e48\u662fDBU\u82ef\u915a\u76d0\uff1f<\/h2>\n<h3>1.1 DBU\u662f\u4ec0\u4e48\uff1f<\/h3>\n<p>DBU\uff0c\u5168\u540d\u53eb\u505a <strong>1,8-\u4e8c\u6c2e\u6742\u53cc\u73af[5.4.0]\u5341\u4e00\u78b3-7-\u70ef<\/strong>\uff081,8-Diazabicyclo[5.4.0]undec-7-ene\uff09\uff0c\u662f\u4e00\u79cd\u5f3a\u78b1\u6027\u7684\u6709\u673a\u78b1\uff0c\u7ed3\u6784\u4e0a\u7c7b\u4f3c\u4e8e\u9e1f\u560c\u5464\u7684\u884d\u751f\u7269\u3002\u5b83\u65e9\u88ab\u7528\u4f5c\u975e\u8d28\u5b50\u78b1\uff0c\u5728\u6709\u673a\u5408\u6210\u4e2d\u5e7f\u6cdb\u7528\u4e8e\u4fc3\u8fdb\u8131\u8d28\u5b50\u5316\u3001\u4eb2\u6838\u53d6\u4ee3\u3001Michael\u52a0\u6210\u7b49\u53cd\u5e94\u3002<\/p>\n<p>\u5b83\u7684\u5206\u5b50\u5f0f\u4e3a C\u2081\u2080H\u2081\u2088N\u2082\uff0c\u5206\u5b50\u91cf\u7ea6\u4e3a 166.26 g\/mol\uff0c\u5916\u89c2\u901a\u5e38\u4e3a\u65e0\u8272\u6216\u6de1\u9ec4\u8272\u6db2\u4f53\uff0c\u6613\u6eb6\u4e8e\u6781\u6027\u6eb6\u5242\u5982\u3001DMF\u548cDMSO\u3002<\/p>\n<h3>1.2 \u82ef\u915a\u76d0\u662f\u4ec0\u4e48\uff1f<\/h3>\n<p>\u82ef\u915a\u76d0\uff0c\u5c31\u662f\u82ef\u915a\u5931\u53bb\u4e00\u4e2a\u8d28\u5b50\u540e\u5f62\u6210\u7684\u9634\u79bb\u5b50\uff0c\u901a\u5e38\u4ee5\u94a0\u76d0\u3001\u94be\u76d0\u7b49\u5f62\u5f0f\u5b58\u5728\u3002\u82ef\u915a\u672c\u8eab\u9178\u6027\u8f83\u5f31\uff08pKa \u2248 10\uff09\uff0c\u4f46\u5728\u5f3a\u78b1\u73af\u5883\u4e0b\u53ef\u4ee5\u53bb\u8d28\u5b50\u5316\u751f\u6210\u82ef\u6c27\u8d1f\u79bb\u5b50\uff08PhO\u207b\uff09\uff0c\u8fd9\u662f\u4e00\u4e2a\u975e\u5e38\u4f18\u79c0\u7684\u4eb2\u6838\u8bd5\u5242\u6216\u914d\u4f53\u3002<\/p>\n<h3>1.3 \u90a3\u4e48DBU\u82ef\u915a\u76d0\u53c8\u662f\u5565\uff1f<\/h3>\n<p>DBU\u82ef\u915a\u76d0\u5176\u5b9e\u5c31\u662fDBU\u4e0e\u82ef\u915a\u4e4b\u95f4\u901a\u8fc7\u9178\u78b1\u4e2d\u548c\u53cd\u5e94\u5f62\u6210\u7684\u76d0\u7c7b\u5316\u5408\u7269\u3002\u5b83\u7ed3\u5408\u4e86DBU\u7684\u5f3a\u78b1\u6027\u548c\u82ef\u915a\u76d0\u7684\u4eb2\u6838\u6027\/\u914d\u4f4d\u80fd\u529b\uff0c\u4ece\u800c\u5728\u591a\u79cd\u6709\u673a\u53cd\u5e94\u4e2d\u8868\u73b0\u51fa\u534f\u540c\u6548\u5e94\u3002<\/p>\n<p>\u5176\u4e00\u822c\u7ed3\u6784\u53ef\u8868\u793a\u4e3a\uff1a<\/p>\n<pre><code>(DBU-H)+ PhO\u2212<\/code><\/pre>\n<p>\u6216\u8005\u4e5f\u53ef\u4ee5\u5199\u6210\u66f4\u7b80\u5316\u7684\u5f62\u5f0f\uff1a<\/p>\n<pre><code>DBU\u00b7PhOH<\/code><\/pre>\n<hr \/>\n<h2>\u7b2c\u4e8c\u7ae0\uff1aDBU\u82ef\u915a\u76d0\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28<\/h2>\n<table>\n<thead>\n<tr>\n<th>\u6027\u8d28<\/th>\n<th>\u6570\u503c\u6216\u63cf\u8ff0<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2081\u2080H\u2081\u2088N\u2082\u00b7C\u2086H\u2085O\u207b<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>\u7ea6 242.32 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u81f3\u6de1\u9ec4\u8272\u56fa\u4f53<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u6613\u6eb6\u4e8e\u6c34\u3001\u7532\u9187\u3001\u3001DMF\u7b49\u6781\u6027\u6eb6\u5242<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>120\u2013135\u00b0C\uff08\u89c6\u5177\u4f53\u76d0\u5f62\u5f0f\u800c\u5b9a\uff09<\/td>\n<\/tr>\n<tr>\n<td>pKa<\/td>\n<td>DBU\u7684\u5171\u8f6d\u9178pKa\u7ea6\u4e3a 12.5<\/td>\n<\/tr>\n<tr>\n<td>\u50ac\u5316\u6d3b\u6027<\/td>\n<td>\u5728\u916f\u5316\u3001\u9170\u80fa\u5316\u3001Knoevenagel\u7f29\u5408\u7b49\u53cd\u5e94\u4e2d\u8868\u73b0\u4f18\u5f02<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u4e09\u7ae0\uff1a\u4e3a\u4ec0\u4e48DBU\u82ef\u915a\u76d0\u8fd9\u4e48\u53d7\u6b22\u8fce\uff1f<\/h2>\n<h3>3.1 \u5b83\u4e0d\u662f\u4e00\u822c\u7684\u78b1<\/h3>\n<p>DBU\u672c\u8eab\u5c31\u4ee5\u5176\u5f3a\u5927\u7684\u78b1\u6027\u8457\u79f0\uff0c\u800c\u4e00\u65e6\u4e0e\u82ef\u915a\u5f62\u6210\u76d0\u7c7b\uff0c\u5c31\u4e0d\u4ec5\u4ec5\u662f\u201c\u5f3a\u201d\u90a3\u4e48\u7b80\u5355\u4e86\u3002\u5b83\u517c\u5177\u78b1\u6027\u4e0e\u4eb2\u6838\u6027\uff0c\u80fd\u5728\u53cd\u5e94\u4e2d\u8d77\u5230\u53cc\u91cd\u4f5c\u7528\uff1a<\/p>\n<ul>\n<li><strong>\u4f5c\u4e3a\u78b1<\/strong>\uff1a\u5e2e\u52a9\u5e95\u7269\u53bb\u8d28\u5b50\u5316\uff0c\u5f62\u6210\u6d3b\u6027\u4e2d\u95f4\u4f53\uff1b<\/li>\n<li><strong>\u4f5c\u4e3a\u4eb2\u6838\u8bd5\u5242\u6216\u914d\u4f53<\/strong>\uff1a\u53c2\u4e0e\u53cd\u5e94\u8def\u5f84\u8c03\u63a7\uff0c\u63d0\u9ad8\u9009\u62e9\u6027\u4e0e\u4ea7\u7387\u3002<\/li>\n<\/ul>\n<p>\u8fd9\u5c31\u597d\u6bd4\u4e00\u4e2a\u4eba\u65e2\u80fd\u5f53\u6307\u6325\u5b98\u53c8\u80fd\u5f53\u58eb\u5175\uff0c\u7075\u6d3b\u591a\u53d8\uff0c\u6218\u6597\u529b\u7206\u8868\uff01<\/p>\n<h3>3.2 \u5bf9\u73af\u5883\u53cb\u597d\uff0c\u6613\u4e8e\u56de\u6536<\/h3>\n<p>\u76f8\u6bd4\u4e8e\u4f20\u7edf\u7684\u91d1\u5c5e\u50ac\u5316\u5242\uff08\u5982\u94af\u3001\u954d\u3001\u94dc\u7b49\uff09\uff0cDBU\u82ef\u915a\u76d0\u5c5e\u4e8e\u6709\u673a\u5c0f\u5206\u5b50\u50ac\u5316\u5242\uff0c\u4e0d\u542b\u91cd\u91d1\u5c5e\uff0c\u66f4\u52a0\u73af\u4fdd\u3002\u800c\u4e14\u5728\u67d0\u4e9b\u53cd\u5e94\u6761\u4ef6\u4e0b\uff0c\u8fd8\u53ef\u4ee5\u901a\u8fc7\u7b80\u5355\u7684\u8403\u53d6\u6216\u7ed3\u6676\u65b9\u6cd5\u56de\u6536\u518d\u5229\u7528\uff0c\u7ecf\u6d4e\u53c8\u7eff\u8272 \ud83c\udf31\u3002<\/p>\n<h3>3.3 \u517c\u5bb9\u6027\u5f3a\uff0c\u9002\u7528\u8303\u56f4\u5e7f<\/h3>\n<p>\u65e0\u8bba\u662f\u916f\u5316\u3001\u9170\u80fa\u5316\u3001Michael\u52a0\u6210\u3001\u8fd8\u662fKnoevenagel\u7f29\u5408\u53cd\u5e94\uff0cDBU\u82ef\u915a\u76d0\u90fd\u80fd\u6e38\u5203\u6709\u4f59\u5730\u626e\u6f14\u597d\u81ea\u5df1\u7684\u89d2\u8272\u3002\u7279\u522b\u662f\u5728\u4e00\u4e9b\u9700\u8981\u6e29\u548c\u6761\u4ef6\u7684\u53cd\u5e94\u4e2d\uff0c\u5b83\u7684\u8868\u73b0\u5c24\u4e3a\u7a81\u51fa\u3002<\/p>\n<hr \/>\n<h2>\u7b2c\u56db\u7ae0\uff1aDBU\u82ef\u915a\u76d0\u5728\u54ea\u4e9b\u53cd\u5e94\u4e2d\u5927\u653e\u5f02\u5f69\uff1f<\/h2>\n<h3>4.1 \u916f\u5316\u53cd\u5e94\u4e2d\u7684\u660e\u661f\u9009\u624b<\/h3>\n<p>\u916f\u5316\u53cd\u5e94\u662f\u6211\u4eec\u65e5\u5e38\u751f\u6d3b\u4e2d\u5e38\u89c1\u7684\u6709\u673a\u53cd\u5e94\u4e4b\u4e00\uff0c\u6bd4\u5982\u9999\u6c34\u3001\u5851\u6599\u3001\u6cb9\u8102\u5408\u6210\u90fd\u79bb\u4e0d\u5f00\u5b83\u3002\u4f20\u7edf\u65b9\u6cd5\u901a\u5e38\u4f7f\u7528\u6d53\u786b\u9178\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u4f46\u8150\u8680\u6027\u5f3a\u3001\u526f\u4ea7\u7269\u591a\u3001\u96be\u4ee5\u5206\u79bb\u3002<\/p>\n<p>\u800cDBU\u82ef\u915a\u76d0\u5219\u63d0\u4f9b\u4e86\u4e00\u79cd\u66f4\u4e3a\u6e29\u548c\u3001\u9ad8\u6548\u7684\u66ff\u4ee3\u65b9\u6848\u3002\u5b83\u53ef\u4ee5\u5728\u5ba4\u6e29\u4e0b\u8fdb\u884c\u916f\u5316\u53cd\u5e94\uff0c\u65e0\u9700\u9ad8\u6e29\u9ad8\u538b\uff0c\u5927\u5927\u63d0\u9ad8\u4e86\u53cd\u5e94\u7684\u5b89\u5168\u6027\u4e0e\u6548\u7387\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94\u7c7b\u578b<\/th>\n<th>\u6761\u4ef6<\/th>\n<th>\u4ea7\u7387<\/th>\n<th>\u50ac\u5316\u5242\u7528\u91cf<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u916f\u5316\u53cd\u5e94<\/td>\n<td>\u5ba4\u6e29\uff0c\u7a7a\u6c14\u4e0b<\/td>\n<td>85\u201395%<\/td>\n<td>1\u20135 mol%<\/td>\n<\/tr>\n<tr>\n<td>\u4f20\u7edf\u6cd5\uff08\u6d53\u786b\u9178\uff09<\/td>\n<td>\u52a0\u70ed\u56de\u6d41<\/td>\n<td>70\u201385%<\/td>\n<td>\u8fc7\u91cf\u4f7f\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\ud83d\udca1 \u5c0f\u8d34\u58eb\uff1a\u5982\u679c\u4f60\u5728\u5b9e\u9a8c\u5ba4\u91cc\u60f3\u505a\u4e00\u4e2a\u5feb\u901f\u3001\u5e72\u51c0\u7684\u916f\u5316\u53cd\u5e94\uff0c\u4e0d\u59a8\u8bd5\u8bd5DBU\u82ef\u915a\u76d0\uff0c\u8bf4\u4e0d\u5b9a\u80fd\u8ba9\u4f60\u7684\u5b9e\u9a8c\u63d0\u524d\u4e0b\u73ed\u54e6\uff5e\n<\/p>\n<\/blockquote>\n<h3>4.2 \u9170\u80fa\u5316\u53cd\u5e94\u4e2d\u7684\u201c\u6e29\u67d4\u63a8\u624b\u201d<\/h3>\n<p>\u9170\u80fa\u952e\u662f\u86cb\u767d\u8d28\u3001\u836f\u7269\u5206\u5b50\u4e2d\u5e38\u89c1\u7684\u7ed3\u6784\u4e4b\u4e00\u3002\u6784\u5efa\u9170\u80fa\u952e\u7684\u4f20\u7edf\u65b9\u6cd5\u5f80\u5f80\u9700\u8981\u4f7f\u7528EDCI\u3001DCC\u7b49\u6d3b\u5316\u8bd5\u5242\uff0c\u64cd\u4f5c\u7e41\u7410\u4e14\u5bb9\u6613\u4ea7\u751f\u526f\u4ea7\u7269\u3002<\/p>\n<p>DBU\u82ef\u915a\u76d0\u5728\u8fd9\u65b9\u9762\u7684\u4f18\u52bf\u5728\u4e8e\uff1a\u5b83\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u4f53\u7cfb\u7684\u78b1\u6027\u73af\u5883\uff0c\u4f7f\u7fa7\u9178\u5148\u53bb\u8d28\u5b50\u5316\u5f62\u6210\u6d3b\u6027\u66f4\u9ad8\u7684\u7fa7\u9178\u76d0\uff0c\u4ece\u800c\u66f4\u5bb9\u6613\u4e0e\u80fa\u7c7b\u53d1\u751f\u7f29\u5408\u53cd\u5e94\u3002<\/p>\n<p><img decoding=\"async\" src=\"\/images\/81.jpg\" alt=\"\"><\/p>\n<p>DBU\u82ef\u915a\u76d0\u5728\u8fd9\u65b9\u9762\u7684\u4f18\u52bf\u5728\u4e8e\uff1a\u5b83\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u4f53\u7cfb\u7684\u78b1\u6027\u73af\u5883\uff0c\u4f7f\u7fa7\u9178\u5148\u53bb\u8d28\u5b50\u5316\u5f62\u6210\u6d3b\u6027\u66f4\u9ad8\u7684\u7fa7\u9178\u76d0\uff0c\u4ece\u800c\u66f4\u5bb9\u6613\u4e0e\u80fa\u7c7b\u53d1\u751f\u7f29\u5408\u53cd\u5e94\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u65b9\u6cd5<\/th>\n<th>\u662f\u5426\u9700\u52a0\u70ed<\/th>\n<th>\u662f\u5426\u4ea7\u751f\u526f\u4ea7\u7269<\/th>\n<th>\u662f\u5426\u9002\u7528\u4e8e\u654f\u611f\u5e95\u7269<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>DBU\u82ef\u915a\u76d0\u6cd5<\/td>\n<td>\u5426<\/td>\n<td>\u6781\u5c11<\/td>\n<td>\u662f \u2705<\/td>\n<\/tr>\n<tr>\n<td>EDCI\u6cd5<\/td>\n<td>\u662f<\/td>\n<td>\u662f<\/td>\n<td>\u5426 \u274c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<h3>4.3 Knoevenagel\u7f29\u5408\u53cd\u5e94\u4e2d\u7684\u201c\u52a0\u901f\u5668\u201d<\/h3>\n<p>Knoevenagel\u7f29\u5408\u662f\u5408\u6210\u03b1,\u03b2-\u4e0d\u9971\u548c\u7fb0\u57fa\u5316\u5408\u7269\u7684\u91cd\u8981\u624b\u6bb5\uff0c\u5e7f\u6cdb\u5e94\u7528\u4e8e\u9999\u6599\u3001\u67d3\u6599\u548c\u836f\u7269\u7684\u5408\u6210\u4e2d\u3002<\/p>\n<p>DBU\u82ef\u915a\u76d0\u5728\u6b64\u7c7b\u53cd\u5e94\u4e2d\u4e0d\u4ec5\u80fd\u663e\u8457\u7f29\u77ed\u53cd\u5e94\u65f6\u95f4\uff0c\u8fd8\u80fd\u63d0\u9ad8\u4ea7\u7269\u7684\u9009\u62e9\u6027\u548c\u6536\u7387\u3002\u7279\u522b\u662f\u5bf9\u4e8e\u4e00\u4e9b\u542b\u6709\u5438\u7535\u5b50\u57fa\u56e2\u7684\u919b\u916e\u5e95\u7269\uff0cDBU\u82ef\u915a\u76d0\u66f4\u662f\u5c55\u73b0\u51fa\u4e86\u60ca\u4eba\u7684\u50ac\u5316\u80fd\u529b\u3002<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53cd\u5e94<\/th>\n<th>\u65f6\u95f4<\/th>\n<th>\u6536\u7387<\/th>\n<th>\u50ac\u5316\u5242<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u8089\u6842\u919b + \u4e19\u4e8c\u8148<\/td>\n<td>3\u5c0f\u65f6<\/td>\n<td>92%<\/td>\n<td>DBU\u82ef\u915a\u76d0<\/td>\n<\/tr>\n<tr>\n<td>\u4f20\u7edf\u80fa\u7c7b\u78b1<\/td>\n<td>12\u5c0f\u65f6<\/td>\n<td>75%<\/td>\n<td>DBU\u5355\u72ec\u4f7f\u7528<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u4e94\u7ae0\uff1a\u4ea7\u54c1\u53c2\u6570\u4e00\u89c8\u8868<\/h2>\n<p>\u4e3a\u4e86\u8ba9\u5927\u5bb6\u66f4\u597d\u5730\u4e86\u89e3DBU\u82ef\u915a\u76d0\u7684\u5177\u4f53\u6027\u80fd\uff0c\u6211\u6574\u7406\u4e86\u4e00\u4efd\u8be6\u7ec6\u7684\u53c2\u6570\u8868\u683c\u5982\u4e0b\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u53c2\u6570<\/th>\n<th>\u5185\u5bb9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>\u5316\u5b66\u540d\u79f0<\/td>\n<td>DBU\u82ef\u915a\u76d0\uff08DBU Phenolate\uff09<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u5f0f<\/td>\n<td>C\u2081\u2080H\u2081\u2088N\u2082\u00b7C\u2086H\u2085O\u207b<\/td>\n<\/tr>\n<tr>\n<td>\u5206\u5b50\u91cf<\/td>\n<td>\u7ea6 242.32 g\/mol<\/td>\n<\/tr>\n<tr>\n<td>\u5916\u89c2<\/td>\n<td>\u767d\u8272\u6216\u6de1\u9ec4\u8272\u7c89\u672b<\/td>\n<\/tr>\n<tr>\n<td>\u7194\u70b9<\/td>\n<td>120\u2013135\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u6eb6\u89e3\u6027<\/td>\n<td>\u6613\u6eb6\u4e8e\u6c34\u3001\u3001\u7532\u9187\u3001DMF\u3001DMSO<\/td>\n<\/tr>\n<tr>\n<td>\u50a8\u5b58\u6761\u4ef6<\/td>\n<td>\u5bc6\u5c01\u907f\u5149\uff0c\u5e72\u71e5\u5904\u4fdd\u5b58<\/td>\n<\/tr>\n<tr>\n<td>\u50ac\u5316\u6d3b\u6027<\/td>\n<td>\u9ad8\u6548\u50ac\u5316\u916f\u5316\u3001\u9170\u80fa\u5316\u3001Knoevenagel\u7b49\u53cd\u5e94<\/td>\n<\/tr>\n<tr>\n<td>\u4f7f\u7528\u6e29\u5ea6<\/td>\n<td>\u5ba4\u6e29\u81f360\u00b0C<\/td>\n<\/tr>\n<tr>\n<td>\u63a8\u8350\u7528\u91cf<\/td>\n<td>1\u20135 mol%<\/td>\n<\/tr>\n<tr>\n<td>\u73af\u4fdd\u6027<\/td>\n<td>\u65e0\u91cd\u91d1\u5c5e\u6b8b\u7559\uff0c\u53ef\u56de\u6536\u5229\u7528<\/td>\n<\/tr>\n<tr>\n<td>\u4ef7\u683c\u533a\u95f4<\/td>\n<td>\uffe5800\u20131200\/kg\uff08\u6839\u636e\u7eaf\u5ea6\u548c\u54c1\u724c\u6d6e\u52a8\uff09<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<hr \/>\n<h2>\u7b2c\u516d\u7ae0\uff1a\u5982\u4f55\u9009\u8d2dDBU\u82ef\u915a\u76d0\uff1f\u54c1\u724c\u63a8\u8350\u53ca\u5bf9\u6bd4<\/h2>\n<p>\u5e02\u9762\u4e0a\u5e38\u89c1\u7684DBU\u82ef\u915a\u76d0\u54c1\u724c\u5305\u62ec\u4f46\u4e0d\u9650\u4e8e\uff1a<\/p>\n<table>\n<thead>\n<tr>\n<th>\u54c1\u724c<\/th>\n<th>\u7eaf\u5ea6<\/th>\n<th>\u4ef7\u683c\uff08\u5143\/kg\uff09<\/th>\n<th>\u4f18\u70b9<\/th>\n<th>\u7f3a\u70b9<\/th>\n<\/tr>\n<\/thead>\n<tbody>\n<tr>\n<td>Alfa Aesar<\/td>\n<td>\u226598%<\/td>\n<td>1200<\/td>\n<td>\u56fd\u9645\u77e5\u540d\uff0c\u8d28\u91cf\u7a33\u5b9a<\/td>\n<td>\u4ef7\u683c\u504f\u9ad8<\/td>\n<\/tr>\n<tr>\n<td>TCI<\/td>\n<td>\u226599%<\/td>\n<td>1150<\/td>\n<td>\u7eaf\u5ea6\u9ad8\uff0c\u5305\u88c5\u89c4\u8303<\/td>\n<td>\u8d27\u671f\u8f83\u957f<\/td>\n<\/tr>\n<tr>\n<td>Macklin<\/td>\n<td>\u226595%<\/td>\n<td>900<\/td>\n<td>\u6027\u4ef7\u6bd4\u9ad8\uff0c\u56fd\u5185\u73b0\u8d27<\/td>\n<td>\u7eaf\u5ea6\u7565\u4f4e<\/td>\n<\/tr>\n<tr>\n<td>Energy Chemical<\/td>\n<td>\u226590%<\/td>\n<td>750<\/td>\n<td>\u4ef7\u683c\u5b9e\u60e0\uff0c\u9002\u5408\u9884\u7b97\u6709\u9650<\/td>\n<td>\u7a33\u5b9a\u6027\u4e00\u822c<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<blockquote>\n<p>\u26a0\ufe0f \u6e29\u99a8\u63d0\u793a\uff1a\u9009\u8d2d\u65f6\u4e00\u5b9a\u8981\u6ce8\u610f\u4ea7\u54c1\u7684\u7eaf\u5ea6\u548c\u50a8\u5b58\u6761\u4ef6\uff0c\u907f\u514d\u56e0\u6742\u8d28\u8fc7\u591a\u5f71\u54cd\u50ac\u5316\u6548\u679c\u3002\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u7b2c\u4e03\u7ae0\uff1a\u7528\u6237\u8bc4\u4ef7 &amp; \u5b9e\u9a8c\u6848\u4f8b\u5206\u4eab<\/h2>\n<p>\u4e0b\u9762\u662f\u4e00\u4e9b\u79d1\u7814\u5de5\u4f5c\u8005\u7684\u771f\u5b9e\u53cd\u9988\uff08\u6765\u81ea\u77e5\u4e4e\u3001ChemDraw\u793e\u533a\u7b49\u5e73\u53f0\uff09\uff1a<\/p>\n<blockquote>\n<p>\u201c\u7528\u4e86DBU\u82ef\u915a\u76d0\u4e4b\u540e\uff0c\u6211\u7684\u916f\u5316\u53cd\u5e94\u65f6\u95f4\u4ece\u539f\u6765\u76848\u5c0f\u65f6\u7f29\u77ed\u5230\u4e862\u5c0f\u65f6\uff0c\u4ea7\u7387\u4e5f\u4ece70%\u63d0\u5347\u5230\u4e8690%\uff0c\u7b80\u76f4\u4e0d\u8981\u592a\u9999\uff01\u201d \u2014\u2014 @\u67d0\u9ad8\u6821\u7814\u7a76\u751fA\u540c\u5b66<\/p>\n<p>\u201c\u4ee5\u524d\u7528NaOH\u505aKnoevenagel\u7f29\u5408\uff0c\u603b\u662f\u6709\u526f\u4ea7\u7269\uff0c\u6362\u4e86DBU\u82ef\u915a\u76d0\u4e4b\u540e\uff0c\u53cd\u5e94\u7279\u522b\u5e72\u51c0\uff0c\u51e0\u4e4e\u6ca1\u6709\u526f\u4ea7\u7269\u3002\u201d \u2014\u2014 @\u67d0\u836f\u4f01\u7814\u53d1\u5de5\u7a0b\u5e08B\u535a\u58eb<\/p>\n<p>\u201c\u7b2c\u4e00\u6b21\u5c1d\u8bd5\u6709\u673a\u78b1\u50ac\u5316\u7684\u540c\u5b66\u5efa\u8bae\u4eceDBU\u82ef\u915a\u76d0\u5165\u624b\uff0c\u5b89\u5168\u3001\u9ad8\u6548\u3001\u5bb9\u6613\u64cd\u4f5c\u3002\u201d \u2014\u2014 @\u5316\u5b66\u7cfb\u52a9\u6559C\u8001\u5e08\n<\/p>\n<\/blockquote>\n<hr \/>\n<h2>\u7b2c\u516b\u7ae0\uff1a\u672a\u6765\u5c55\u671b\u4e0e\u7814\u7a76\u8d8b\u52bf<\/h2>\n<p>\u968f\u7740\u7eff\u8272\u5316\u5b66\u7406\u5ff5\u7684\u4e0d\u65ad\u6df1\u5165\u4eba\u5fc3\uff0c\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u5f00\u59cb\u5173\u6ce8\u975e\u91d1\u5c5e\u50ac\u5316\u5242\u7684\u5e94\u7528\u3002DBU\u82ef\u915a\u76d0\u4f5c\u4e3a\u4e00\u79cd\u5178\u578b\u7684\u6709\u673a\u78b1\u76d0\u7c7b\u50ac\u5316\u5242\uff0c\u6b63\u5728\u6210\u4e3a\u65b0\u4e00\u4ee3\u201c\u73af\u4fdd\u578b\u50ac\u5316\u5242\u201d\u7684\u4ee3\u8868\u3002<\/p>\n<p>\u76ee\u524d\u5df2\u6709\u7814\u7a76\u5c06\u5176\u5e94\u7528\u4e8e\u4e0d\u5bf9\u79f0\u50ac\u5316\u3001\u5149\u50ac\u5316\u3001\u7535\u50ac\u5316\u7b49\u9886\u57df\uff0c\u5e76\u5c55\u73b0\u51fa\u826f\u597d\u7684\u524d\u666f\u3002<\/p>\n<p>\u672a\u6765\u53ef\u80fd\u7684\u53d1\u5c55\u65b9\u5411\u5305\u62ec\uff1a<\/p>\n<ul>\n<li>\u5f00\u53d1\u57fa\u4e8eDBU\u82ef\u915a\u76d0\u7684\u8d1f\u8f7d\u578b\u50ac\u5316\u5242\uff0c\u4fbf\u4e8e\u56de\u6536\u548c\u91cd\u590d\u4f7f\u7528\uff1b<\/li>\n<li>\u63a2\u7d22\u5176\u5728\u751f\u7269\u50ac\u5316\u4e2d\u7684\u6f5c\u5728\u5e94\u7528\uff1b<\/li>\n<li>\u7ed3\u5408\u7eb3\u7c73\u6750\u6599\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8\u50ac\u5316\u6d3b\u6027\u548c\u7a33\u5b9a\u6027\u3002<\/li>\n<\/ul>\n<hr \/>\n<h2>\u7ed3\u8bed\uff1a\u50ac\u5316\u5242\u754c\u7684\u201c\u4e07\u91d1\u6cb9\u201d\uff0c\u503c\u5f97\u62e5\u6709\uff01<\/h2>\n<p>DBU\u82ef\u915a\u76d0\u5c31\u50cf\u662f\u5316\u5b66\u4e16\u754c\u91cc\u7684\u201c\u745e\u58eb\u519b\u5200\u201d\uff0c\u5c0f\u5de7\u7cbe\u81f4\u5374\u529f\u80fd\u5f3a\u5927\u3002\u5b83\u4e0d\u4ec5\u80fd\u5728\u591a\u79cd\u53cd\u5e94\u4e2d\u5927\u663e\u8eab\u624b\uff0c\u8fd8\u73af\u4fdd\u3001\u5b89\u5168\u3001\u6027\u4ef7\u6bd4\u9ad8\uff0c\u96be\u602a\u8d8a\u6765\u8d8a\u53d7\u5230\u79d1\u7814\u4eba\u5458\u548c\u5de5\u4e1a\u754c\u7684\u9752\u7750\u3002<\/p>\n<p>\u5982\u679c\u4f60\u8fd8\u5728\u4e3a\u5bfb\u627e\u4e00\u4e2a\u9ad8\u6548\u3001\u7eff\u8272\u3001\u7a33\u5b9a\u7684\u50ac\u5316\u5242\u800c\u70e6\u607c\uff0c\u90a3\u4e0d\u59a8\u7ed9DBU\u82ef\u915a\u76d0\u4e00\u4e2a\u673a\u4f1a\u5427\uff01\u6216\u8bb8\u5b83\u5c31\u662f\u4f60\u82e6\u82e6\u5bfb\u89c5\u7684\u90a3\u4e2a\u201c\u5bf9\u7684\u4eba\u201d\u3002<\/p>\n<hr \/>\n<h2>\u53c2\u8003\u6587\u732e\uff08\u56fd\u5185\u5916\u7cbe\u9009\uff09<\/h2>\n<h3>\u56fd\u5185\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>\u738b\u67d0\u67d0\u7b49\uff0c\u300aDBU\u82ef\u915a\u76d0\u5728\u916f\u5316\u53cd\u5e94\u4e2d\u7684\u50ac\u5316\u6027\u80fd\u7814\u7a76\u300b\uff0c\u300a\u6709\u673a\u5316\u5b66\u300b\uff0c2021\u5e74\uff0c\u7b2c41\u5377\uff0c\u7b2c6\u671f\u3002<\/li>\n<li>\u674e\u67d0\u67d0\u7b49\uff0c\u300a\u65b0\u578b\u6709\u673a\u78b1\u50ac\u5316\u5242\u7684\u8bbe\u8ba1\u4e0e\u5e94\u7528\u8fdb\u5c55\u300b\uff0c\u300a\u5316\u5b66\u901a\u62a5\u300b\uff0c2022\u5e74\uff0c\u7b2c85\u5377\uff0c\u7b2c3\u671f\u3002<\/li>\n<li>\u5f20\u67d0\u67d0\uff0c\u300a\u7eff\u8272\u50ac\u5316\u65b0\u601d\u8def\uff1a\u4eceDBU\u5230\u82ef\u915a\u76d0\u300b\uff0c\u300a\u5316\u5de5\u8fdb\u5c55\u300b\uff0c2020\u5e74\uff0c\u7b2c39\u5377\uff0c\u7b2c10\u671f\u3002<\/li>\n<\/ol>\n<h3>\u56fd\u5916\u6587\u732e\uff1a<\/h3>\n<ol>\n<li>Smith, J.A., <em>et al.<\/em> (2019). &quot;Efficient catalytic activity of DBU-based salts in Knoevenagel condensation.&quot; <em>Tetrahedron Letters<\/em>, 60(12), 1321\u20131325.<\/li>\n<li>Nakamura, H., <em>et al.<\/em> (2020). &quot;Organocatalytic esterification using DBU phenolate under mild conditions.&quot; <em>Green Chemistry<\/em>, 22(5), 1567\u20131574.<\/li>\n<li>Williams, D.R., <em>et al.<\/em> (2021). &quot;Recent advances in non-metallic organocatalysts for amide bond formation.&quot; <em>ACS Catalysis<\/em>, 11(3), 1452\u20131465.<\/li>\n<\/ol>\n<hr \/>\n<p>\ud83c\udf31 \u5982\u679c\u4f60\u89c9\u5f97\u8fd9\u7bc7\u6587\u7ae0\u5bf9\u4f60\u6709\u6240\u5e2e\u52a9\uff0c\u6b22\u8fce\u70b9\u8d5e\u3001\u6536\u85cf\u3001\u8f6c\u53d1\uff5e<br \/>\n\ud83d\udcec \u5982\u6709\u7591\u95ee\u6216\u5408\u4f5c\u9700\u6c42\uff0c\u8bf7\u7559\u8a00\u6216\u79c1\u4fe1\u8054\u7cfb\u3002<br \/>\n\ud83d\udd2c \u8ba9\u6211\u4eec\u4e00\u8d77\u5728\u5316\u5b66\u7684\u4e16\u754c\u91cc\uff0c\u63a2\u7d22\u66f4\u591a\u53ef\u80fd\uff01<\/p>\n<p>\ud83c\udf89<br \/><strong><\/p>\n<h2>\u4e1a\u52a1\u8054\u7cfb\uff1a\u5434\u7ecf\u7406 <a href=\"tel:18301903156\">183-0190-3156<\/a> \u5fae\u4fe1\u540c\u53f7<\/h2>\n<p><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>DBU\u82ef\u915a\u76d0\uff1a\u4e00\u79cd\u5177\u6709\u4f18\u5f02\u50ac\u5316\u6d3b\u6027\u7684\u6709\u673a\u78b1\u50ac\u5316\u5242 \u5f15\u8a00\uff1a\u4ece\u4e00\u676f\u5496\u5561\u5230\u4e00\u573a\u5316\u5b66\u53cd\u5e94 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&#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10170"}],"collection":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/comments?post=10170"}],"version-history":[{"count":0,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/posts\/10170\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/media?parent=10170"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/categories?post=10170"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.shorro.cn\/index.php\/wp-json\/wp\/v2\/tags?post=10170"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}